Discovery of a novel peptide capable to prevent biofilm formation by Staphylococcus aureus

In a recent study published in PNAS, the team of Yves Dufrêne (FNRS research director and WELBIO investigator at the Université Catholique de Louvain) has identified, together with the Trinity College Dublin, a new molecule capable of preventing the formation of S. aureus biofilms.

They discovered that a peptide derived from the neuronal cell adhesion molecule β-neurexin is able to inhibit SdrC-dependent attachment to inert surfaces, cell-cell adhesion, and biofilm formation. These findings raise the possibility that the peptide could be used as a platform for designing a peptidomimetic with potential to prevent biofilm infections. This breakthrough relies on live cell nanoscopy, recently reviewed in Nature.

Références : Feuillie C. et Al, Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC. PNAS (2017) doi: 10.1073/pnas.1616805114

Last update : 28/4/2017 - Vie privée - Printable version -  © 2020 WELBIO

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