News 2015
Discovery of a new mechanism that controls the final number of cerebral cortical neurons

In a study published in Developmental Cell, the group of Dr Laurent NGUYEN, Research Associates of the FRS-FNRS / WELBIO Investigator at GIGA-Neurosciences, Université de Liège, has discovered a new mechanism that sets the final number of neurons in the cerebral cortex. Blocking this molecular mechanism prevents the formation of the appropriate number of cortical neurons and results in microcephaly. This work is a collaboration with the laboratory of Dr. Sebastian LEIDEL at the Max Planck Institute for Molecular Biomedicine in Münster, Germany.

Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons

In collaboration with the group of Prof. F. Barras (CNRS, Université d’Aix-Marseille), the team of Prof. J.F. Collet, WELBIO investigator at UCL, discovered a new system (named MsrPQ) allowing bacteria to fight bleach. The scientists from both teams worked in close collaboration. Their results are published today in the prestigious journal Nature.

Cédric Blanpain Winner of the Joseph Maisin 2015 Prize for Basic Biomedical Sciences

Cédric Blanpain, Full Professor at ULB and WELBIO Investigator, is winner of the Joseph Maisin 2015 Prize for Basic Biomedical Sciences

Kick-off of the WELBIO 2015 research programmes

The laureates of the FRFS-WELBIO 2015 call for projects met yesterday for a kick-off session at the WELBIO premises. Fourteen new projects are funded in various life science domains

Causal link between aneuploidy and cancer

A research team led by Cédric Blanpain, WELBIO investigator at ULB, shows the causal link between aneuploidy and cancer. Their study has been published in Nature Cell Biology.

Phospholipids act as direct allosteric modulators of G protein–coupled receptors activity

A research team led by Cédric Govaerts, WELBIO Investigator at ULB, has shown that G protein–coupled receptor activity can vary from one tissue to another. This finding suggests that drugs targeting a specific receptor could trigger different responses in different organs. The results of this team from the Université libre de Bruxelles and Stanford University – Brian Kobilka, Nobel Prize 2012 – have been published in Nature Chemical Biology.

ELP3, an effector of constitutive Wnt signaling in the intestine

In a study published in The Journal of Experimental Medicine, the group of Alain Chariot, WELBIO Investigator at ULg, has defined the acetylase ELP3 as one effector of constitutive Wnt signaling in the intestine.

Dr Laurent Nguyen (ULg), laureate of the 2015 Pierre and Simone Clerdent Foundation Prize

Dr Laurent Nguyen, WELBIO Investigator at GIGA-Neurosciences (University of Liège) is the 2015 winner of the triennial prize awarded by the Pierre and Simone Clerdent Foundation.

A new step towards understanding the bacterial defense mechanisms

In a study published in Nature Structural and Molecular Biology, the group of Jean-François Collet, WELBIO investigator at UCL, describe the three-dimensional structure of CcdA, a membrane protein involved in the bacterial defenses against oxidative stress

How a blood protein help us resist against infection by the parasite Trypanosoma brucei

In a study published in Nature Communications, researchers lead by Etienne Pays, WELBIO Investigator at ULB, describe the mechanism used by the serum apolipoprotein L1 to resist infection by the parasite Trypanosoma brucei.

New genetic alterations involved in the development of skin squamous cell carcinoma

Dans une étude publiée dans Nature Medicine, les chercheurs de l’équipe de Cédric Blanpain, Investigateur WELBIO à l’ULB, identifient de nouvelles anomalies génétiques impliquées dans le développement, la progression et les métastases des carcinomes spinocellulaires murins et démontrent leurs similitudes avec les carcinomes spinocellulaires humains.

Sox9 and skin basal cell carcinoma.

n a study published in Cell Stem Cell, researchers led by Cédric Blanpain, WELBIO investigator at ULB, report that Sox9 controls skin cancer formation by regulating the expansion of tumor initiating cells and the invasive properties of cancer cells.

Annual report 2014

WELBIO is counting 23 research programmes of excellence and established financial resources to initate the valorisation of results generated by its research. In 2014, in the new context of the FRFS, a new call for projects was launched.

EGFR and NF-κB : partners in cancer

In a review published in Trends in Molecular Medicine, Alain Chariot, Investigator WELBIO at ULg, and colleagues present new perspectives for combination treatments against cancer based on the role played by EGFR and NF-κB in that disease.

Innate capacity of our immune system to fight against viruses

In a study published in Nature Communication, the group of Stanislas Goriely, WELBIO investigator at ULB, describe the cellular and molecular mechanisms implicated in the innate capacity of our immune system to fight against viruses.

Patrice Cani, recipient of the 2015 grant for medical research from the InBev-Baillet-Latour Foundation.

Patrice Cani, Investigateur WELBIO à l’UCL, a reçu le prestigieux crédit InBev-Baillet-Latour pour son projet de recherches dans le domaine des troubles métaboliques. Son travail porte sur la compréhension du dialogue entre le tissu adipeux et le microbiote intestinal ainsi que du rôle des lipides bioactifs sur le déclenchement des troubles métaboliques associés à l’obésité et au diabète.

Breakthrough towards a novel form of cancer immunotherapy

A research team led by Pierre Coulie, WELBIO investigator at UCL, proposes a new approach to treat cancer. Work by the UCL group published in the prestigious journal Science Translational Medicine opens the way to a new form of cancer immunotherapy, which could improve the efficiency of current treatments

Dialogue between the adipose tissue and the gut microbiota

The research team of Prof. Patrice D. Cani, WELBIO investigator at UCL, discovered that one enzyme from the adipose tissue contribute to the regulation of body weight by a mechanism involving the development of adipocyte cells oxidizing lipids. The discovery is published in Nature Communications.

Moving towards repairing the damaged cerebral cortex by cell therapy

The work of researchers led by Pierre Vanderhaeghen, Investigator WELBIO at ULB, opens new perspectives for the repair of damaged cerebral cortex by cell replacement. This work is published in the prestigious journal Neuron.

Lancement de l'appel à projets 2015

L’appel à projets 2015 est lancé, pour des projets de recherche fondamentale dans les domaines des sciences de la vie pouvant conduire à des applications dans tous les champs de la (bio)technologie, y compris la prévention, le diagnostic et le traitement. Celui-ci est ouvert aux chercheurs ‘juniors’ ainsi qu’aux chercheurs établis.

Twist 1 in tumour initiation, growth and progression in skin squamous cell carcinoma.

In a study making the cover of Cell Stem Cell, researchers led by Cédric Blanpain, Investigator WELBIO at ULB, report the mechanisms regulating the different functions of Twist1 controlling skin tumour initiation, cancer stem cell function and tumor progression.

Last update : 21/1/2015 - Vie privée - Printable version -  © 2020 WELBIO

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