In a study published in Developmental Cell, the group of Dr Laurent NGUYEN, Research Associates of the FRS-FNRS / WELBIO Investigator at GIGA-Neurosciences, Université de Liège, has discovered a new mechanism that sets the final number of neurons in the cerebral cortex. Blocking this molecular mechanism prevents the formation of the appropriate number of cortical neurons and results in microcephaly. This work is a collaboration with the laboratory of Dr. Sebastian LEIDEL at the Max Planck Institute for Molecular Biomedicine in Münster, Germany.
In collaboration with the group of Prof. F. Barras (CNRS, Université d’Aix-Marseille), the team of Prof. J.F. Collet, WELBIO investigator at UCL, discovered a new system (named MsrPQ) allowing bacteria to fight bleach. The scientists from both teams worked in close collaboration. Their results are published today in the prestigious journal Nature.
Cédric Blanpain, Full Professor at ULB and WELBIO Investigator, is winner of the Joseph Maisin 2015 Prize for Basic Biomedical Sciences
The laureates of the FRFS-WELBIO 2015 call for projects met yesterday for a kick-off session at the WELBIO premises. Fourteen new projects are funded in various life science domains
A research team led by Cédric Blanpain, WELBIO investigator at ULB, shows the causal link between aneuploidy and cancer. Their study has been published in Nature Cell Biology.
A research team led by Cédric Govaerts, WELBIO Investigator at ULB, has shown that G protein–coupled receptor activity can vary from one tissue to another. This finding suggests that drugs targeting a specific receptor could trigger different responses in different organs. The results of this team from the Université libre de Bruxelles and Stanford University – Brian Kobilka, Nobel Prize 2012 – have been published in Nature Chemical Biology.
In a study published in The Journal of Experimental Medicine, the group of Alain Chariot, WELBIO Investigator at ULg, has defined the acetylase ELP3 as one effector of constitutive Wnt signaling in the intestine.
Dr Laurent Nguyen, WELBIO Investigator at GIGA-Neurosciences (University of Liège) is the 2015 winner of the triennial prize awarded by the Pierre and Simone Clerdent Foundation.
In a study published in Nature Structural and Molecular Biology, the group of Jean-François Collet, WELBIO investigator at UCL, describe the three-dimensional structure of CcdA, a membrane protein involved in the bacterial defenses against oxidative stress
In a study published in Nature Communications, researchers lead by Etienne Pays, WELBIO Investigator at ULB, describe the mechanism used by the serum apolipoprotein L1 to resist infection by the parasite Trypanosoma brucei.
Dans une étude publiée dans Nature Medicine, les chercheurs de l’équipe de Cédric Blanpain, Investigateur WELBIO à l’ULB, identifient de nouvelles anomalies génétiques impliquées dans le développement, la progression et les métastases des carcinomes spinocellulaires murins et démontrent leurs similitudes avec les carcinomes spinocellulaires humains.
n a study published in Cell Stem Cell, researchers led by Cédric Blanpain, WELBIO investigator at ULB, report that Sox9 controls skin cancer formation by regulating the expansion of tumor initiating cells and the invasive properties of cancer cells.
WELBIO is counting 23 research programmes of excellence and established financial resources to initate the valorisation of results generated by its research. In 2014, in the new context of the FRFS, a new call for projects was launched.
In a review published in Trends in Molecular Medicine, Alain Chariot, Investigator WELBIO at ULg, and colleagues present new perspectives for combination treatments against cancer based on the role played by EGFR and NF-κB in that disease.
In a study published in Nature Communication, the group of Stanislas Goriely, WELBIO investigator at ULB, describe the cellular and molecular mechanisms implicated in the innate capacity of our immune system to fight against viruses.
Patrice Cani, Investigateur WELBIO à l’UCL, a reçu le prestigieux crédit InBev-Baillet-Latour pour son projet de recherches dans le domaine des troubles métaboliques. Son travail porte sur la compréhension du dialogue entre le tissu adipeux et le microbiote intestinal ainsi que du rôle des lipides bioactifs sur le déclenchement des troubles métaboliques associés à l’obésité et au diabète.
A research team led by Pierre Coulie, WELBIO investigator at UCL, proposes a new approach to treat cancer. Work by the UCL group published in the prestigious journal Science Translational Medicine opens the way to a new form of cancer immunotherapy, which could improve the efficiency of current treatments
The research team of Prof. Patrice D. Cani, WELBIO investigator at UCL, discovered that one enzyme from the adipose tissue contribute to the regulation of body weight by a mechanism involving the development of adipocyte cells oxidizing lipids. The discovery is published in Nature Communications.
The work of researchers led by Pierre Vanderhaeghen, Investigator WELBIO at ULB, opens new perspectives for the repair of damaged cerebral cortex by cell replacement. This work is published in the prestigious journal Neuron.
L’appel à projets 2015 est lancé, pour des projets de recherche fondamentale dans les domaines des sciences de la vie pouvant conduire à des applications dans tous les champs de la (bio)technologie, y compris la prévention, le diagnostic et le traitement. Celui-ci est ouvert aux chercheurs ‘juniors’ ainsi qu’aux chercheurs établis.
In a study making the cover of Cell Stem Cell, researchers led by Cédric Blanpain, Investigator WELBIO at ULB, report the mechanisms regulating the different functions of Twist1 controlling skin tumour initiation, cancer stem cell function and tumor progression.