Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner
07/07/2014

In a study published in the Proceedings of the National Academy of Sciences USA, researchers lead by André Goffinet, WELBIO investigator at the Université catholique de Louvain (UCL), Belgium,  report on the essential roles played by the membrane proteins Celsr2, Celsr3 and Fzd3 during anterior brain development.

Connections are crucial to brain function and a variety of molecular systems direct axonal growth during development and regeneration. An important system involves Celsr2, Celsr3 and Fzd3, membrane proteins that also regulate epithelial planar cell polarity (PCP). Here, the researchers show genetically that Celsr2 and Celsr3 guide axons redundantly, in collaboration with Fzd3 in the same cell populations. However, unlike in epithelial PCP, their action is Vangl1 and Vangl2-independent. Furthermore, expression of Celsr2-3 and Fzd3 in thalamocortical axons and cortical cells is required for the fine mapping of cortical areas. Those findings that Celsr2, Celsr3 and Fzd3 regulate axonal guidance using mechanisms different than epithelial PCP have implications for brain wiring during normal development and regeneration.

Qu et al. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 doi: 10.1073/pnas.1402105111


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