A new step towards understanding the bacterial defense mechanisms
22/09/2015

In a study published in Nature Structural and Molecular Biology, the group of Jean-François Collet, WELBIO investigator at UCL, describe the three-dimensional structure of CcdA, a membrane protein involved in the bacterial defenses against oxidative stress

 CcdA is a membrane protein involved in the defense mechanisms of Gram negative bacteria against oxidative stress.
Solving the structure of this protein by nuclear magnetic resonance (NMR) has been a technical challenge and took more than 5 years.  The structure improves our understanding of how bacteria reduces oxidizing molecules in the cell envelope.
The work in the lab of Prof. J.F. Collet, WELBIO investigator, was carried out by Dr. Seung-Hyun Cho with the support of the WELBIO.

J. A. Williamson, Structure and multistate function of the transmembrane electron transporter CcdA, Nature Strucutral and Molecular Biology (2015), doi 10.1038/nsmb.3099


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