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Publication in Nature Communications

A novel immunotherapy to fight cancer

Combining two complementary immunotherapies increases the efficacy of treatments against cancer

Sophie Lucas (WELBIO – UCLouvain) and her team neutralize a molecule that blocks immune responses against cancer. This novel form of immunotherapy induces tumor regressions by strongly increasing the efficacy of another well-known immunotherapy.

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Publication in Science Translational Medicine

Discovery of a novel gene involved in primary lymphedema

Identifying the genetic causes is crucial for a better management of the disease

The Human Molecular Genetics laboratory headed by Miikka Vikkula (WELBIO – UCLouvain) identified a gene responsible for primary lymphedema, a discovery essential for proper diagnosis and opening possibilities for the development of treatments.

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Publication in Nature

Cell-cell communication in stem cell fate choice identified

the molecular mechanisms that control multipotency in different tissues, which have important implications for cancer formation

Researchers led by Cédric Blanpain (WELBIO – ULB) identify for the first time the mechanisms by which cell-cell communication control the fate of mammary and prostate stem cells.

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Publication dans Nature

Expansion de la peau: mécanisme dévoilé

Mécanismes moléculaires de génération de la peau

Cédric Blanpain (WELBIO - ULB) et son équipe identifient pour la première fois la manière dont l’étirement active les cellules souches de la peau pour induire l’expansion tissulaire.

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Annual report 2019

Information on our projects portfolio, WELBIO investigators, their publications and the awards they received as well as technology transfer progresses.

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Publication in eLife

Ammonium’s journey across cell membranes

Ammonia and the proton are transported separately

Anna Maria Marini et Mélanie Boeckstaens (ULB) with teams from Strathclyde and Dundee show that the AmtB protein from the bacteria E. coli separately translocates ammonia and the proton, the ion being carried out by two chains of water molecules.

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Publication in Nature Chemical Biology

Click! Resistant bacteria caught in the act

Antibiotic resistance

A team led by Jean-François Collet (WELBIO investigator at UCLouvain), offers an unprecedented perspective on the defense mechanisms of bacteria, contributing to the global effort to respond to antibiotic resistance.

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Publication in Cell

Mechanisms responsible for tissue growth

Developmental progenitors control the optimality of postnatal

Cédric Blanpain (ULB) and his team uncover the mechanisms mediating postnatal tissue development. They found that a unique developmental stem cell population mediates tissue expansion by a constant self-duplication throughout postnatal development.

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Publication in Nature

A better understanding of embryonic development

Isabelle Migeotte (WELBIO 2015-2019 - ULB) and her colleagues clarify a key stage of embryonic development. This data is essential for improving the production of synthetic embryos and limit the use of animal embryos.

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Publication in Nature Communications

Type 1 diabetes: how interferon-α impacts human pancreatic β-cells

Decio L. Eizirik (WELBIO - ULB) and colleagues used a multi-omics approach to clarify the impact of interferon-α on human beta cells.

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Publication in Nature Reviews Endocrinology

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

In a recent review paper, Decio L. Eizirik (WELBIO investigator at ULB) and colleagues discuss the mechanisms leading to pancreatic beta cell failure in diabetes.

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COVID-19 : Research & Innovation

COVID-19 : research, innovation and expertise in Wallonia and Brussels

Find on a dedicated wesite all the projects set up at ULiège and in many other organisations in the Wallonia-Brussels Federation to fight against the virus and its consequences on health, society and the economy.

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