Luc Bertrand's research focuses on post-translational modifications involved in the regulation of the metabolism and cardiac function. He studies more specifically the role of the AMPK protein.
Sophie Lucas studies the mechanisms whereby Regulatory T cells (Tregs) inhibit the immune system, preventing it from attacking healthy tissue.
Agnes Noel’s work focuses mainly on tumour vascularisation, in particular on the formation of new lymphatic vessels (lymphangiogenesis), a biological process which contributes to cancer progression and metastasis dissemination towards lymph nodes.
David Alsteens investigates, at the molecular level, the forces at play in protein structures, in cellular adhesion, in ligand-receptor binding or in the binding of the virus to the cell it is infecting.
Guido Bommer studies the role enzymes, the function of which is still unknown, might play in cancer metabolism. Unexpected results regularly lead him to look at other diseases.
Amandine Everard investigates the involvement of the bacteria of the intestinal microbiota in the regulation of food intake, in particular the intestine-to-brain axis.
Esteban Gurzov aims to understand molecular basis of metabolic pathophysiology. He investigates more specifically the role of phosphatases in metabolic diseases and their complications, such as cancer.
Regis Hallez works on the regulation of bacterial stress by (p)ppGpp. This “alarmone”, which is produced by virtually all bacteria in response to fluctuations in nutrient availability, profoundly reshapes the bacterial physiology.
Cedric Blanpain studies the role of stem cells in development, homeostasis and cancer, investigating the mechanisms behind tumour heterogeneity, metastasis and resistance to therapy.
Alain Chariot investigates the role of genes that are not well characterised but are associated with genetic disorders when they lose their function, in cancer models. This project focuses on protein reprogramming in immune responses and cancer.
Jean-Francois aims to understand how bacterial cells defend themselves against external aggressions, in order to improve our ability to combat them. He studies, in particular, the oxidative stress and envelope stress.
Decio L. Eizirik aims to understand the pathogenesis of type-1 diabetes (T1D), more specifically the role of diabetes genes, endoplasmic reticulum stress and alternative splicing in pancreatic β cell deficiencies.
Benoît Van den Eynde studies tumour immunology, in particular, the mechanisms for the production of tumour antigens and the mechanisms whereby tumours escape immune attacks.
Miikka Vikkula aims to identify and characterise genetic variants that cause certain human diseases.
Jean-Luc Balligand studies cardiac remodelling, i.e. molecular and biological modifications of the cardiac muscle under stress (for example, a heart attack). This remodelling, which is characterised by cardiac hypertrophy, leads to heart failure.
Pierre Coulie’s research focuses on tumour immunology. His expertise in CD8 cytolytic T-cells and the antigens they recognise is used here to study severe autoimmune diseases.
The research of Stefan Constantinescu is dedicated to myeloproliferative neoplasms, a group of hematopoietic stem cell pathologies that lead to an excessive production of blood cells.
Francois Fuks’ research is dedicated to epigenetics and its role in cancer. Epigenetic alterations are mainly known as changes in DNA and histones. RNA epigenetics is emerging as a brand-new field of research.
Anna Maria Marini’s research is dedicated to the transport of ammonium ions (NH4+) and to the role this transport plays in various physiological and pathological contexts.
Pierre van der Bruggen aims to understand why cytotoxic T-cells are not successful in killing tumour cells.
Benjamin Beck investigates different groups of oesophageal cancers in order to identify genes required for tumour growth and progression, as well as resistance to treatment.
Pierre Close studies transfer RNA modication and protein translation reprogramming supporting the expression of specific proteomes that are required for the survival of cancer cells, the formation of metastases and resistance to treatment.
Abel Garcia-Pino studies the molecular bases for the survival of bacteria and, in particular, bacterial persistence, a physiological restart mechanism that allows certain cells to resist a wide variety of stresses.
Thomas Marichal aims to understand how epithelial cell dysfunction contributes to inflammatory diseases such as chronic inflammatory bowel diseases or asthma.
Benoit Vanhollebeke aims to gain a better understanding of neurovascular signalling, the basis of the blood-brain barrier, the finely regulated interface between the brain and the vascular system which isolates synaptic communication from the blood.
Fabrice Bureau investigates the «’ANTI’ mechanisms which naturally prevent the development of aberrant immune responses in the respiratory mucosae.
Patrice Cani studies the interactions between the gut microbiota, the host and biological systems such as the endocannabinoid system and the innate immunity in obesity, type 2 diabetes and metabolic inflammation.
Marc Parmentier has focused for many years on the characterization of orphan G protein-coupled receptors. He concentrates now on the functional characterization of specific ligand/receptor systems.
