Early diagnosis: can protein tyrosine phosphatase activity predict obesity-induced hepatocellular carcinoma?
cancer • biological analysis • metabolism
Esteban Gurzov is Research Associate at the FNRS. At the Université libre de Bruxelles, he leads the “ Signal Transduction and Metabolism ” laboratory of the ULB Center for Diabetes Research. His laboratory aims to understand molecular basis of metabolic pathophysiology. He investigates more specifically the role of phosphatases in metabolic diseases and their complications, such as cancer.
This project is focused on obesity-induced hepatocellular carcinoma. Recent studies suggest that, under oxidative stress, protein tyrosine phosphatases play a key role in the transition from obesity to non-alcoholic steato-hepatitis and hepatocellular carcinoma. The expression and oxidation of protein tyrosine phosphatases will be characterised in human liver biopsies, based on which a risk profile will be defined for early diagnosis, stratification and personalised treatment of obesity-associated hepatocellular carcinoma.