Wobble transfer RNA modifications optimize dynamic proteome expression
This work shows that a large majority of genes are insensitive to U34-tRNA modifications. On the other hand, for a certain number of genes, these modifications are essential during their translation, otherwise, the proteins produced are unstable and are degraded. These results pave the way for a more systematic prediction of the identity of proteins for which expression depends on the regulation of the numerous modifications of tRNAs.
Source : Communiqué de presse ULiège